Clinical Pharmacology of Janus Kinase Inhibitors in Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease
Inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, are disabling conditions characterised by chronic, relapsing inflammation of the gastrointestinal tract. Current treatments are not universally effective or, in the case of therapeutic antibodies, are hampered by immune responses. Janus kinase inhibitors are orally delivered small molecules that target cytokine signall...
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Inflammatory bowel diseases (IBD) including most important forms; Crohn’s disease (CD) and ulcerative colitis (UC); are chronic diseases affecting the gastrointestinal tract with unclear etiology and pathology. The role of gut microbiota has recently been considered as major a factor, since altered microbiome or "dysbiosis" is a key player in the protracted course of inflammation in IBD. Howeve...
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متن کاملAdvances in the Inhibitors of Janus Kinase
In recent years, for the lesion site, studies at the molecular level of drugs targeting protein molecules has been a major research method for exploiting new, high-efficiency drugs with low toxicity [1]. Janus kinases (JAKs) are important signal transducers of many cytokines, growth factors and interferon. In recent years, it has been found in cancer cells and cells transfected with oncogenes t...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2020
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjaa014